Combatting Proteostasis Imbalance in Age-Related Neurodegenerative Disorders: Targeted Modulation of Molecular Chaperone Networks
Keywords:
Proteostasis, Neurodegeneration, Molecular Chaperones, CRISPR-Cas9, Protein Misfolding, Alzheimer's Disease, Parkinson's DiseaseAbstract
Proteostasis imbalance is a hallmark of age-related neurodegenerative diseases. This study investigates the modulation of molecular chaperone networks to restore proteostasis in cellular models of Alzheimer's and Parkinson's diseases. Using cutting-edge CRISPR-Cas9 gene editing and proteomics, we identified key chaperones capable of ameliorating protein misfolding. The results demonstrate that targeted chaperone modulation can significantly reduce proteotoxic stress, offering insights into therapeutic strategies for neurodegeneration.
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