Optimization of 3D-Printed Biocompatible Scaffolds Using Additive Manufacturing Techniques for Enhanced Osseointegration in Dental Implants

Jordan Hall; Quinn Turner; Skyler Turner; Rowan Edwards

Authors

Jordan Hall PhD
Quinn Turner Professor
Skyler Turner Associate Professor
Rowan Edwards D.Sc

Keywords:

3D printing, osseo-integration, biocompatible scaffolds, additive manufacturing, dental implants, mesenchymal stem cells, scaffold optimization

Abstract

The integration of dental implants remains a challenge due to insufficient osseointegration rates. This study explores advanced additive manufacturing techniques to optimize 3D-printed biocompatible scaffolds, enhancing osseointegration. Utilizing a custom-built fiber extrusion system, we produced scaffolds with varied porosity. Bone marrow-derived mesenchymal stem cells (BM-MSCs) were seeded onto these scaffolds and analyzed for proliferation and differentiation using quantitative PCR and histological methods. Our findings reveal that scaffolds with 50% porosity significantly enhanced BM-MSC proliferation (p < 0.01) and osteogenic differentiation compared to conventional titanium implants. This research provides critical insights into biomaterials engineering for improving dental implant longevity and efficacy, addressing the pressing issue of implant failure in clinical settings.

Author Biographies

Jordan Hall, PhD

PhD
Harvard University
1350 Massachusetts Ave, Cambridge, MA 02138, USA

Quinn Turner, Professor

Professor
Technical University of Munich
Arcisstraße 21, 80333 München, Germany

Skyler Turner, Associate Professor

Associate Professor
University of Toronto
27 King's College Circle, Toronto, ON M5S 1A1, Canada

Rowan Edwards, D.Sc

D.Sc
University of Melbourne
Parkville, VIC 3010, Australia

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