Reassessing the Paradigms of Antimicrobial Stewardship: A Critical Analysis of Historical and Contemporary Practices in Clinical Medicine

Abstract

Antimicrobial resistance (AMR) has emerged as a global health crisis, necessitating a thorough re-evaluation of antimicrobial stewardship (AMS) strategies. This study employs a systematic literature review and meta-analysis to critically assess historical approaches to AMS and to propose an integrated framework that incorporates modern technological advancements, including artificial intelligence and big data analytics. Our findings reveal significant discrepancies between traditional protocols and emerging best practices, urging clinicians to adopt a more nuanced understanding of AMR dynamics. The proposed framework aims to enhance clinical outcomes and optimize resource utilization, demonstrating that a strategic shift in AMS practices is essential for current and future healthcare systems.