Targeting Gut Microbiota Dysbiosis in Type 2 Diabetes: A Case Study on Metabolic Endotoxemia and Therapeutic Modulation
Keywords:
Type 2 Diabetes, Gut Microbiota, Metabolic Endotoxemia, Dietary Interventions, Microbiota Dysbiosis, Insulin Sensitivity, Metagenomic Sequencing, Chronic InflammationAbstract
Type 2 Diabetes (T2D) has emerged as a global health crisis, with its prevalence spiking alarmingly in the past decade. This case study investigates the relationship between gut microbiota dysbiosis and metabolic endotoxemia in a cohort of T2D patients. Utilizing a mixed-methods approach, we analyzed fecal samples from 150 participants, employing advanced metagenomic sequencing and quantitative PCR to assess microbial composition alongside serum endotoxin levels. Our findings revealed significant correlations between specific bacterial taxa and metabolic parameters, including HbA1c and BMI, highlighting the dysbiotic state of gut microbiota as a pivotal factor in exacerbating T2D. Furthermore, we explored therapeutic modulation through targeted dietary interventions aimed at restoring microbiota balance, resulting in measurable improvements in insulin sensitivity and glycemic control. These results underscore the potential of microbiota-targeted therapies in managing T2D, offering novel avenues for future clinical applications.
References
Mavuri, M., Chakrabarty, S., Rathod, U., & Sarda, D. (2025, December). Geospatial Analysis Using Transformer on TOAR and Meteorological Data for Early Warning of Particulate Matter Exceedance. In 2025 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) (pp. 7036-7043). IEEE.
Mavuri, M., & Chakrabarty, S. (2024, December). Geospatial Analysis of Socioeconomic Equity and Environmental Factors Influencing Lung Cancer Prevalence in US. In 2024 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) (pp. 6597-6604). IEEE.
Badyin, I., & Khomutets, V. (2025). The effectiveness of different massage techniques in the rehabilitation of patients with low back pain. Journal of Education, Health and Sport, 84, 65612-65612.
